利福平溶液(50mg/ml)

Rifampicin Solution（50mg/ml）

● 產(chǎn)品包裝：

Formula: C₄₃H₅₈N₄O₁₂

MW: 822.94

Appearance: clear red solution

● 產(chǎn)品簡介：

Rifis highly active against Gram-positive bacteria, such as staphylococci, streptococci, pneumococci but is less active against Gram-negative organisms.Rifhas activity against a wide range of microorganisms such as mycobacteria including Mycobacterium tuberculosis and M. leprae. The minimum inhibitory concentrations (MIC) for the most sensitive microorganisms (chlamydia, staphylococci) are in the range of about 0.01-0.02 μg/ml. The inhibitory activity ofRifremained practically unchanged between pH 5.5-8.0.Rifinhibits bacterial DNA-dependent RNA polymerase (the enzyme responsible for DNA transcription) by forming a stable enzyme-drug complex with the ?-subunit of RNA polymerase (RNAP-Rif), rpoB gene (binding constant of 10-9 Mat37°C).Rifsuppresses the initiation of chain formation (but not chain elongation) in RNA synthesis. There is some inhibition of mammalian RNA polymerases at much higher concentrations ofRifthan that for bacterial RNA polymerases.Rifhas also antifungal activity probably due to some other mechanism of action than inhibition of a fungal RNA polymerase.

● 保存條件：

   -20℃保存。有效期12個月。

● References:

1. Karlson, A.G. and Ulrich, J.A., Stability of Rifampin in Dimethylsulfoxide Appl. Microbiol., 18, 692, 1969.